Shank3 Exons 14–16 Deletion in Glutamatergic Neurons Leads to Social and Repetitive Behavioral Deficits Associated With Increased Cortical Layer 2/3 Neuronal Excitability

Shank3, an abundant excitatory postsynaptic scaffolding protein, has been associated with multiple brain disorders, including autism spectrum disorders (ASD) and Phelan-McDermid syndrome (PMS). However, how cell type-specific Shank3 deletion affects disease-related neuronal and brain functions remai...

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Detalles Bibliográficos
Publicado en:Front Cell Neurosci
Main Authors: Yoo, Taesun, Cho, Heejin, Park, Haram, Lee, Jiseok, Kim, Eunjoon
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2019
Assuntos:
Neuroscience
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6795689/
https://ncbi.nlm.nih.gov/pubmed/31649512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2019.00458
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