Shank2 Deletion in Parvalbumin Neurons Leads to Moderate Hyperactivity, Enhanced Self-Grooming and Suppressed Seizure Susceptibility in Mice

Shank2 is an abundant postsynaptic scaffolding protein implicated in neurodevelopmental and psychiatric disorders, including autism spectrum disorders (ASD). Deletion of Shank2 in mice has been shown to induce social deficits, repetitive behaviors, and hyperactivity, but the identity of the cell typ...

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Detalles Bibliográficos
Publicado en:Front Mol Neurosci
Autores principales: Lee, Seungjoon, Lee, Eunee, Kim, Ryunhee, Kim, Jihye, Lee, Suho, Park, Haram, Yang, Esther, Kim, Hyun, Kim, Eunjoon
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2018
Materias:
Neuroscience
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6018407/
https://ncbi.nlm.nih.gov/pubmed/29970987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2018.00209
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