GABA Neuronal Deletion of Shank3 Exons 14–16 in Mice Suppresses Striatal Excitatory Synaptic Input and Induces Social and Locomotor Abnormalities

Shank3 is an excitatory postsynaptic scaffolding protein implicated in multiple brain disorders, including autism spectrum disorders (ASD) and Phelan-McDermid syndrome (PMS). Although previous neurobiological studies on Shank3 and Shank3-mutant mice have revealed diverse roles of Shank3 in the regul...

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Detalles Bibliográficos
Publicado en:Front Cell Neurosci
Main Authors: Yoo, Taesun, Cho, Heejin, Lee, Jiseok, Park, Haram, Yoo, Ye-Eun, Yang, Esther, Kim, Jin Yong, Kim, Hyun, Kim, Eunjoon
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2018
Assuntos:
Neuroscience
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6189516/
https://ncbi.nlm.nih.gov/pubmed/30356810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2018.00341
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