GABA Neuronal Deletion of Shank3 Exons 14–16 in Mice Suppresses Striatal Excitatory Synaptic Input and Induces Social and Locomotor Abnormalities

Shank3 is an excitatory postsynaptic scaffolding protein implicated in multiple brain disorders, including autism spectrum disorders (ASD) and Phelan-McDermid syndrome (PMS). Although previous neurobiological studies on Shank3 and Shank3-mutant mice have revealed diverse roles of Shank3 in the regul...

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Bibliographic Details
Published in:Front Cell Neurosci
Main Authors: Yoo, Taesun, Cho, Heejin, Lee, Jiseok, Park, Haram, Yoo, Ye-Eun, Yang, Esther, Kim, Jin Yong, Kim, Hyun, Kim, Eunjoon
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2018
Subjects:
Neuroscience
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6189516/
https://ncbi.nlm.nih.gov/pubmed/30356810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2018.00341
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