Shank2 Deletion in Parvalbumin Neurons Leads to Moderate Hyperactivity, Enhanced Self-Grooming and Suppressed Seizure Susceptibility in Mice

Shank2 is an abundant postsynaptic scaffolding protein implicated in neurodevelopmental and psychiatric disorders, including autism spectrum disorders (ASD). Deletion of Shank2 in mice has been shown to induce social deficits, repetitive behaviors, and hyperactivity, but the identity of the cell typ...

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Detalhes bibliográficos
Publicado no:Front Mol Neurosci
Main Authors: Lee, Seungjoon, Lee, Eunee, Kim, Ryunhee, Kim, Jihye, Lee, Suho, Park, Haram, Yang, Esther, Kim, Hyun, Kim, Eunjoon
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6018407/
https://ncbi.nlm.nih.gov/pubmed/29970987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2018.00209
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