Shank3 Mice Carrying the Human Q321R Mutation Display Enhanced Self-Grooming, Abnormal Electroencephalogram Patterns, and Suppressed Neuronal Excitability and Seizure Susceptibility

Shank3, a postsynaptic scaffolding protein involved in regulating excitatory synapse assembly and function, has been implicated in several brain disorders, including autism spectrum disorders (ASD), Phelan-McDermid syndrome, schizophrenia, intellectual disability, and mania. Here we generated and ch...

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Vydáno v:Front Mol Neurosci
Hlavní autoři: Yoo, Ye-Eun, Yoo, Taesun, Lee, Seungjoon, Lee, Jiseok, Kim, Doyoun, Han, Hye-Min, Bae, Yong-Chul, Kim, Eunjoon
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2019
Témata:
Neuroscience
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6591539/
https://ncbi.nlm.nih.gov/pubmed/31275112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2019.00155
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