Shank3 Mice Carrying the Human Q321R Mutation Display Enhanced Self-Grooming, Abnormal Electroencephalogram Patterns, and Suppressed Neuronal Excitability and Seizure Susceptibility

Shank3, a postsynaptic scaffolding protein involved in regulating excitatory synapse assembly and function, has been implicated in several brain disorders, including autism spectrum disorders (ASD), Phelan-McDermid syndrome, schizophrenia, intellectual disability, and mania. Here we generated and ch...

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Detalhes bibliográficos
Publicado no:Front Mol Neurosci
Main Authors: Yoo, Ye-Eun, Yoo, Taesun, Lee, Seungjoon, Lee, Jiseok, Kim, Doyoun, Han, Hye-Min, Bae, Yong-Chul, Kim, Eunjoon
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6591539/
https://ncbi.nlm.nih.gov/pubmed/31275112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2019.00155
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