Shank3-mutant mice lacking exon 9 show altered excitation/inhibition balance, enhanced rearing, and spatial memory deficit

Shank3 is a postsynaptic scaffolding protein implicated in synapse development and autism spectrum disorders. The Shank3 gene is known to produce diverse splice variants whose functions have not been fully explored. In the present study, we generated mice lacking Shank3 exon 9 (Shank3(Δ9) mice), and...

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Vydáno v:Front Cell Neurosci
Hlavní autoři: Lee, Jiseok, Chung, Changuk, Ha, Seungmin, Lee, Dongmin, Kim, Do-Young, Kim, Hyun, Kim, Eunjoon
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2015
Témata:
Neuroscience
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4365696/
https://ncbi.nlm.nih.gov/pubmed/25852484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2015.00094
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