Linked dual-class HIV resistance mutations are associated with treatment failure

We hypothesized that HIV-1 with dual-class but not single-class drug resistance mutations linked on the same viral genome, present in the virus population before initiation of antiretroviral therapy (ART), would be associated with failure of ART to suppress viremia. To test this hypothesis, we utili...

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Publicado en:JCI Insight
Main Authors: Boltz, Valerie F., Shao, Wei, Bale, Michael J., Halvas, Elias K., Luke, Brian, McIntyre, James A., Schooley, Robert T., Lockman, Shahin, Currier, Judith S., Sawe, Fred, Hogg, Evelyn, Hughes, Michael D., Kearney, Mary F., Coffin, John M., Mellors, John W.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 2019
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6795402/
https://ncbi.nlm.nih.gov/pubmed/31487271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.130118
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