Rab5 Mediates an Amyloid Precursor Protein Signaling Pathway That Leads to Apoptosis

Alzheimer's disease (AD) involves activation of apoptotic pathways that may be regulated through signaling cascades initiated by the amyloid precursor protein (APP). Enlarged endosomes have been observed in postmortem AD brains at very early stages of the disease. We show here that exogenous ex...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Laifenfeld, Daphna, Patzek, Lucas J., McPhie, Donna L., Chen, Yuzhi, Levites, Yona, Cataldo, Anne M., Neve, Rachael L.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2007
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6794581/
https://ncbi.nlm.nih.gov/pubmed/17611268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4599-06.2007
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