DNA Synthesis and Neuronal Apoptosis Caused by Familial Alzheimer Disease Mutants of the Amyloid Precursor Protein Are Mediated by the p21 Activated Kinase PAK3

Apoptotic pathways and DNA synthesis are activated in neurons in the brains of individuals with Alzheimer disease (AD). However, the signaling mechanisms that mediate these events have not been defined. We show that expression of familial AD (FAD) mutants of the amyloid precursor protein (APP) in pr...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: McPhie, Donna L., Coopersmith, Robert, Hines-Peralta, Andrew, Chen, Yuzhi, Ivins, Kathryn J., Manly, Susan P., Kozlowski, Michael R., Neve, Kim A., Neve, Rachael L.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2003
Assuntos:
Cellular/Molecular
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6740729/
https://ncbi.nlm.nih.gov/pubmed/12890786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.23-17-06914.2003
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