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DNA Synthesis and Neuronal Apoptosis Caused by Familial Alzheimer Disease Mutants of the Amyloid Precursor Protein Are Mediated by the p21 Activated Kinase PAK3

Apoptotic pathways and DNA synthesis are activated in neurons in the brains of individuals with Alzheimer disease (AD). However, the signaling mechanisms that mediate these events have not been defined. We show that expression of familial AD (FAD) mutants of the amyloid precursor protein (APP) in pr...

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Bibliografiske detaljer
Udgivet i:J Neurosci
Main Authors: McPhie, Donna L., Coopersmith, Robert, Hines-Peralta, Andrew, Chen, Yuzhi, Ivins, Kathryn J., Manly, Susan P., Kozlowski, Michael R., Neve, Kim A., Neve, Rachael L.
Format: Artigo
Sprog:Inglês
Udgivet: Society for Neuroscience 2003
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6740729/
https://ncbi.nlm.nih.gov/pubmed/12890786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.23-17-06914.2003
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