Stable Complexes Involving Acetylcholinesterase and Amyloid-β Peptide Change the Biochemical Properties of the Enzyme and Increase the Neurotoxicity of Alzheimer’s Fibrils

Brain acetylcholinesterase (AChE) forms stable complexes with amyloid-β peptide (Aβ) during its assembly into filaments, in agreement with its colocalization with the Aβ deposits of Alzheimer’s brain. The association of the enzyme with nascent Aβ aggregates occurs as early as after 30 min of incubat...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:J Neurosci
Main Authors: Alvarez, Alejandra, Alarcón, Rodrigo, Opazo, Carlos, Campos, Eliseo O., Muñoz, Francisco José, Calderón, Frances H., Dajas, Federico, Gentry, Mary K., Doctor, Bhupendra P., De Mello, Fernando G., Inestrosa, Nibaldo C.
Format: Artigo
Jezik:Inglês
Izdano: Society for Neuroscience 1998
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6792661/
https://ncbi.nlm.nih.gov/pubmed/9547230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.18-09-03213.1998
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