Stable Complexes Involving Acetylcholinesterase and Amyloid-β Peptide Change the Biochemical Properties of the Enzyme and Increase the Neurotoxicity of Alzheimer’s Fibrils

Brain acetylcholinesterase (AChE) forms stable complexes with amyloid-β peptide (Aβ) during its assembly into filaments, in agreement with its colocalization with the Aβ deposits of Alzheimer’s brain. The association of the enzyme with nascent Aβ aggregates occurs as early as after 30 min of incubat...

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Pubblicato in:J Neurosci
Autori principali: Alvarez, Alejandra, Alarcón, Rodrigo, Opazo, Carlos, Campos, Eliseo O., Muñoz, Francisco José, Calderón, Frances H., Dajas, Federico, Gentry, Mary K., Doctor, Bhupendra P., De Mello, Fernando G., Inestrosa, Nibaldo C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society for Neuroscience 1998
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6792661/
https://ncbi.nlm.nih.gov/pubmed/9547230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.18-09-03213.1998
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