Acetylcholinesterase-Aβ Complexes Are More Toxic than Aβ Fibrils in Rat Hippocampus : Effect on Rat β-Amyloid Aggregation, Laminin Expression, Reactive Astrocytosis, and Neuronal Cell Loss

Neuropathological changes generated by human amyloid-β peptide (Aβ) fibrils and Aβ-acetylcholinesterase (Aβ-AChE) complexes were compared in rat hippocampus in vivo. Results showed that Aβ-AChE complexes trigger a more dramatic response in situ than Aβ fibrils alone as characterized by the following...

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Hauptverfasser: Reyes, Ariel E., Chacón, Marcelo A., Dinamarca, Margarita C., Cerpa, Waldo, Morgan, Carlos, Inestrosa, Nibaldo C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Investigative Pathology 2004
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1615768/
https://ncbi.nlm.nih.gov/pubmed/15161650
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