A Genome-Wide Knockout Screen in Human Macrophages Identified Host Factors Modulating Salmonella Infection

A genome-scale CRISPR knockout library screen of THP-1 human macrophages was performed to identify loss-of-function mutations conferring resistance to Salmonella uptake. The screen identified 183 candidate genes, from which 14 representative genes involved in actin dynamics (ACTR3, ARPC4, CAPZB, TOR...

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Bibliografske podrobnosti
izdano v:mBio
Main Authors: Yeung, Amy T. Y., Choi, Yoon Ha, Lee, Amy H. Y., Hale, Christine, Ponstingl, Hannes, Pickard, Derek, Goulding, David, Thomas, Mark, Gill, Erin, Kim, Jong Kyoung, Bradley, Allan, Hancock, Robert E. W., Dougan, Gordon
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2019
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6786873/
https://ncbi.nlm.nih.gov/pubmed/31594818
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.02169-19
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