A Genome-Wide Knockout Screen in Human Macrophages Identified Host Factors Modulating Salmonella Infection

A genome-scale CRISPR knockout library screen of THP-1 human macrophages was performed to identify loss-of-function mutations conferring resistance to Salmonella uptake. The screen identified 183 candidate genes, from which 14 representative genes involved in actin dynamics (ACTR3, ARPC4, CAPZB, TOR...

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Bibliografiske detaljer
Udgivet i:mBio
Main Authors: Yeung, Amy T. Y., Choi, Yoon Ha, Lee, Amy H. Y., Hale, Christine, Ponstingl, Hannes, Pickard, Derek, Goulding, David, Thomas, Mark, Gill, Erin, Kim, Jong Kyoung, Bradley, Allan, Hancock, Robert E. W., Dougan, Gordon
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2019
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6786873/
https://ncbi.nlm.nih.gov/pubmed/31594818
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.02169-19
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