A Genome-Wide Knockout Screen in Human Macrophages Identified Host Factors Modulating Salmonella Infection

A genome-scale CRISPR knockout library screen of THP-1 human macrophages was performed to identify loss-of-function mutations conferring resistance to Salmonella uptake. The screen identified 183 candidate genes, from which 14 representative genes involved in actin dynamics (ACTR3, ARPC4, CAPZB, TOR...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:mBio
मुख्य लेखकों: Yeung, Amy T. Y., Choi, Yoon Ha, Lee, Amy H. Y., Hale, Christine, Ponstingl, Hannes, Pickard, Derek, Goulding, David, Thomas, Mark, Gill, Erin, Kim, Jong Kyoung, Bradley, Allan, Hancock, Robert E. W., Dougan, Gordon
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: American Society for Microbiology 2019
विषय:
Research Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC6786873/
https://ncbi.nlm.nih.gov/pubmed/31594818
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.02169-19
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