A Genome-Wide Knockout Screen in Human Macrophages Identified Host Factors Modulating Salmonella Infection

A genome-scale CRISPR knockout library screen of THP-1 human macrophages was performed to identify loss-of-function mutations conferring resistance to Salmonella uptake. The screen identified 183 candidate genes, from which 14 representative genes involved in actin dynamics (ACTR3, ARPC4, CAPZB, TOR...

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Publicat a:mBio
Autors principals: Yeung, Amy T. Y., Choi, Yoon Ha, Lee, Amy H. Y., Hale, Christine, Ponstingl, Hannes, Pickard, Derek, Goulding, David, Thomas, Mark, Gill, Erin, Kim, Jong Kyoung, Bradley, Allan, Hancock, Robert E. W., Dougan, Gordon
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2019
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6786873/
https://ncbi.nlm.nih.gov/pubmed/31594818
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.02169-19
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