Polymorphic Expression of UGT1A9 is Associated with Variable Acetaminophen Glucuronidation in Neonates: A Population Pharmacokinetic and Pharmacogenetic Study

INTRODUCTION: Acetaminophen (paracetamol, APAP) is widely used as an analgesic and antipyretic drug in children and neonates. A number of enzymes contribute to the metabolism of acetaminophen, and genetic factors might be important to explain variability in acetaminophen metabolism among individuals...

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Publicado en:Clin Pharmacokinet
Main Authors: Linakis, Matthew W., Cook, Sarah F., Kumar, Shaun S., Liu, Xiaoxi, Wilkins, Diana G., Gaedigk, Roger, Gaedigk, Andrea, Sherwin, Catherine M. T., van den Anker, John N.
Formato: Artigo
Idioma:Inglês
Publicado: 2018
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6785200/
https://ncbi.nlm.nih.gov/pubmed/29654492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40262-018-0634-9
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