Polymorphic Expression of UGT1A9 is Associated with Variable Acetaminophen Glucuronidation in Neonates: A Population Pharmacokinetic and Pharmacogenetic Study

INTRODUCTION: Acetaminophen (paracetamol, APAP) is widely used as an analgesic and antipyretic drug in children and neonates. A number of enzymes contribute to the metabolism of acetaminophen, and genetic factors might be important to explain variability in acetaminophen metabolism among individuals...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Clin Pharmacokinet
Hauptverfasser: Linakis, Matthew W., Cook, Sarah F., Kumar, Shaun S., Liu, Xiaoxi, Wilkins, Diana G., Gaedigk, Roger, Gaedigk, Andrea, Sherwin, Catherine M. T., van den Anker, John N.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
Schlagworte:
Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6785200/
https://ncbi.nlm.nih.gov/pubmed/29654492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40262-018-0634-9
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge