Neonatal Maturation of Paracetamol (Acetaminophen) Glucuronidation, Sulfation, and Oxidation Based on a Parent-Metabolite Population Pharmacokinetic Model

OBJECTIVES: This study aimed to model the population pharmacokinetics of intravenous paracetamol and its major metabolites in neonates and to identify influential patient characteristics, especially those affecting the formation clearance (CL(formation)) of oxidative pathway metabolites. METHODS: Ne...

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Publicat a:Clin Pharmacokinet
Autors principals: Cook, Sarah F., Stockmann, Chris, Samiee-Zafarghandy, Samira, King, Amber D., Deutsch, Nina, Williams, Elaine F., Wilkins, Diana G., Sherwin, Catherine M. T., van den Anker, John N.
Format: Artigo
Idioma:Inglês
Publicat: 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5572771/
https://ncbi.nlm.nih.gov/pubmed/27209292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40262-016-0408-1
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