Neonatal Maturation of Paracetamol (Acetaminophen) Glucuronidation, Sulfation, and Oxidation Based on a Parent-Metabolite Population Pharmacokinetic Model

OBJECTIVES: This study aimed to model the population pharmacokinetics of intravenous paracetamol and its major metabolites in neonates and to identify influential patient characteristics, especially those affecting the formation clearance (CL(formation)) of oxidative pathway metabolites. METHODS: Ne...

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Detalhes bibliográficos
Publicado no:Clin Pharmacokinet
Main Authors: Cook, Sarah F., Stockmann, Chris, Samiee-Zafarghandy, Samira, King, Amber D., Deutsch, Nina, Williams, Elaine F., Wilkins, Diana G., Sherwin, Catherine M. T., van den Anker, John N.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5572771/
https://ncbi.nlm.nih.gov/pubmed/27209292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40262-016-0408-1
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