Neonatal Maturation of Paracetamol (Acetaminophen) Glucuronidation, Sulfation, and Oxidation Based on a Parent-Metabolite Population Pharmacokinetic Model

OBJECTIVES: This study aimed to model the population pharmacokinetics of intravenous paracetamol and its major metabolites in neonates and to identify influential patient characteristics, especially those affecting the formation clearance (CL(formation)) of oxidative pathway metabolites. METHODS: Ne...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
izdano v:Clin Pharmacokinet
Main Authors: Cook, Sarah F., Stockmann, Chris, Samiee-Zafarghandy, Samira, King, Amber D., Deutsch, Nina, Williams, Elaine F., Wilkins, Diana G., Sherwin, Catherine M. T., van den Anker, John N.
Format: Artigo
Jezik:Inglês
Izdano: 2016
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5572771/
https://ncbi.nlm.nih.gov/pubmed/27209292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40262-016-0408-1
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki