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Characterization of 17-dihydroexemestane glucuronidation: potential role of the UGT2B17 deletion in exemestane pharmacogenetics

OBJECTIVE: Exemestane is a third-generation aromatase inhibitor used in the treatment of breast cancer in postmenopausal women. Reduction to form 17-dihydroexemestane and subsequent glucuronidation to exemestane-17-O-glucuronide is a major pathway for exemestane metabolism. The goal of this study wa...

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Detalhes bibliográficos
Main Authors: Sun, Dongxiao, Chen, Gang, Dellinger, Ryan W., Sharma, Arun K., Lazarus, Philip
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3076703/
https://ncbi.nlm.nih.gov/pubmed/20697310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FPC.0b013e32833b04af
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