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Characterization of tamoxifen and 4-hydroxytamoxifen glucuronidation by human UGT1A4 variants
INTRODUCTION: Tamoxifen (TAM) is an antiestrogen widely used in the treatment and prevention of breast cancer in women. One of the major mechanisms of metabolism of TAM and one of its major active metabolites, 4-hydroxytamoxifen (4-OH-TAM), is via glucuronidation. In the present study, the glucuroni...
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| Autors principals: | , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
BioMed Central
2006
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1779459/ https://ncbi.nlm.nih.gov/pubmed/16884532 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/bcr1539 |
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