C Terminus of Presenilin Is Required for Overproduction of Amyloidogenic Aβ42 through Stabilization and Endoproteolysis of Presenilin

Mutations in presenilin (PS) genes cause early onset familial Alzheimer's disease (FAD) by increasing production of the amyloidogenic form of amyloid β peptides ending at residue 42 (Aβ42). To identify a PS subdomain responsible for overproduction of Aβ42, we analyzed neuro2a cell lines express...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Tomita, Taisuke, Takikawa, Rie, Koyama, Akihiko, Morohashi, Yuichi, Takasugi, Nobumasa, Saido, Takaomi C., Maruyama, Kei, Iwatsubo, Takeshi
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 1999
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ARTICLE
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6784929/
https://ncbi.nlm.nih.gov/pubmed/10594046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.19-24-10627.1999
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