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The presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid β protein ending at the 42nd (or 43rd) residue

To gain insights into the significance of presenilins (PS) in the pathogenetic mechanisms of early-onset familial Alzheimer disease (FAD), we expressed cDNAs for wild-type PS2 and PS2 with the Volga German (N141I) mutation in cultured cells and then examined the metabolism of the transfected protein...

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Publicat a:Proc Natl Acad Sci U S A
Autors principals: Tomita, Taisuke, Maruyama, Kei, Saido, Takaomi C., Kume, Hideaki, Shinozaki, Kohki, Tokuhiro, Shinya, Capell, Anja, Walter, Jochen, Grünberg, Jürgen, Haass, Christian, Iwatsubo, Takeshi, Obata, Kunihiko
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 1997
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC20036/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9050898/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.5.2025
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