Affect of Presenilin Mutations on APP Cleavage; Insights into the Pathogenesis of FAD

Alzheimer disease (AD) is characterized by progressive memory loss, reduction in cognitive functions, and damage to the brain. The β-amyloid precursor protein can be sequentially cleaved by β- secretase and γ-secretase. Mutations in the presenilin1（PS1） are the most common cause of Familial Alzheime...

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Auteurs principaux:	Nuomin eLi, Kefu eLiu, Yunjie eQiu, Zehui eRen, Rongji eDai, Yulin eDeng, Hong eQing
Format:	Artigo
Langue:	Inglês
Publié:	Frontiers Media S.A. 2016-03-01
Collection:	Frontiers in Aging Neuroscience
Sujets:	liquid chromatography-mass spectrometry Amyloid β-peptide γ-secretases Familial Alzheimer’s disease Presenilin1
Accès en ligne:	http://journal.frontiersin.org/Journal/10.3389/fnagi.2016.00051/full
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