Mechanism of intramembrane cleavage of alcadeins by γ-secretase.
<h4>Background</h4>Alcadein proteins (Alcs; Alcα, Alcβand Alcγ) are predominantly expressed in neurons, as is Alzheimer's β-amyloid (Aβ) precursor protein (APP). Both Alcs and APP are cleaved by primary α- or β-secretase to generate membrane-associated C-terminal fragments (CTFs). Alc CTFs are furth...
Gespeichert in:
| Hauptverfasser: | , , , , , , , |
|---|---|
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Public Library of Science (PLoS)
2013-01-01
|
| Schriftenreihe: | PLoS ONE |
| Online-Zugang: | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23658629/pdf/?tool=EBI |
| Tags: |
Keine Tags, Fügen Sie das erste Tag hinzu!
|