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Cerebral Amyloid Induces Aberrant Axonal Sprouting and Ectopic Terminal Formation in Amyloid Precursor Protein Transgenic Mice

A characteristic feature of Alzheimer’s disease (AD) is the formation of amyloid plaques in the brain. Although this hallmark pathology has been well described, the biological effects of plaques are poorly understood. To study the effect of amyloid plaques on axons and neuronal connectivity, we have...

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Pubblicato in:J Neurosci
Autori principali: Phinney, Amie L., Deller, Thomas, Stalder, Martina, Calhoun, Michael E., Frotscher, Michael, Sommer, Bernd, Staufenbiel, Matthias, Jucker, Mathias
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society for Neuroscience 1999
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6783025/
https://ncbi.nlm.nih.gov/pubmed/10493755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.19-19-08552.1999
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