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Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology
Mutations in the amyloid precursor protein (APP) gene cause early-onset familial Alzheimer disease (AD) by affecting the formation of the amyloid β (Aβ) peptide, the major constituent of AD plaques. We expressed human APP(751) containing these mutations in the brains of transgenic mice. Two transgen...
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| Autores principales: | , , , , , , , , , , , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
The National Academy of Sciences of the USA
1997
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC24301/ https://ncbi.nlm.nih.gov/pubmed/9371838 |
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