Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology

Mutations in the amyloid precursor protein (APP) gene cause early-onset familial Alzheimer disease (AD) by affecting the formation of the amyloid β (Aβ) peptide, the major constituent of AD plaques. We expressed human APP(751) containing these mutations in the brains of transgenic mice. Two transgen...

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Bibliographic Details
Main Authors: Sturchler-Pierrat, Christine, Abramowski, Dorothee, Duke, Mairead, Wiederhold, Karl-Heinz, Mistl, Claudia, Rothacher, Sabin, Ledermann, Birgit, Bürki, Kurt, Frey, Peter, Paganetti, Paolo A., Waridel, Caroline, Calhoun, Michael E., Jucker, Mathias, Probst, Alphonse, Staufenbiel, Matthias, Sommer, Bernd
Format: Artigo
Language:Inglês
Published: The National Academy of Sciences of the USA 1997
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC24301/
https://ncbi.nlm.nih.gov/pubmed/9371838
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