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Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology

Mutations in the amyloid precursor protein (APP) gene cause early-onset familial Alzheimer disease (AD) by affecting the formation of the amyloid β (Aβ) peptide, the major constituent of AD plaques. We expressed human APP(751) containing these mutations in the brains of transgenic mice. Two transgen...

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Publicado no:Proc Natl Acad Sci U S A
Principais autores: Sturchler-Pierrat, Christine, Abramowski, Dorothee, Duke, Mairead, Wiederhold, Karl-Heinz, Mistl, Claudia, Rothacher, Sabin, Ledermann, Birgit, Bürki, Kurt, Frey, Peter, Paganetti, Paolo A., Waridel, Caroline, Calhoun, Michael E., Jucker, Mathias, Probst, Alphonse, Staufenbiel, Matthias, Sommer, Bernd
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 1997
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC24301/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9371838/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.24.13287
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