Neuronal overexpression of mutant amyloid precursor protein results in prominent deposition of cerebrovascular amyloid

Transgenic mice that overexpress mutant human amyloid precursor protein (APP) exhibit one hallmark of Alzheimer’s disease pathology, namely the extracellular deposition of amyloid plaques. Here, we describe significant deposition of amyloid β (Aβ) in the cerebral vasculature [cerebral amyloid angiop...

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Bibliografische gegevens
Hoofdauteurs: Calhoun, Michael E., Burgermeister, Patrick, Phinney, Amie L., Stalder, Martina, Tolnay, Markus, Wiederhold, Karl-Heinz, Abramowski, Dorothee, Sturchler-Pierrat, Christine, Sommer, Bernd, Staufenbiel, Matthias, Jucker, Mathias
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 1999
Onderwerpen:
Biological Sciences
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC24195/
https://ncbi.nlm.nih.gov/pubmed/10570203
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