Neuronal overexpression of mutant amyloid precursor protein results in prominent deposition of cerebrovascular amyloid

Transgenic mice that overexpress mutant human amyloid precursor protein (APP) exhibit one hallmark of Alzheimer’s disease pathology, namely the extracellular deposition of amyloid plaques. Here, we describe significant deposition of amyloid β (Aβ) in the cerebral vasculature [cerebral amyloid angiop...

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Detalhes bibliográficos
Main Authors: Calhoun, Michael E., Burgermeister, Patrick, Phinney, Amie L., Stalder, Martina, Tolnay, Markus, Wiederhold, Karl-Heinz, Abramowski, Dorothee, Sturchler-Pierrat, Christine, Sommer, Bernd, Staufenbiel, Matthias, Jucker, Mathias
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 1999
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC24195/
https://ncbi.nlm.nih.gov/pubmed/10570203
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