Neuronal overexpression of mutant amyloid precursor protein results in prominent deposition of cerebrovascular amyloid

Transgenic mice that overexpress mutant human amyloid precursor protein (APP) exhibit one hallmark of Alzheimer’s disease pathology, namely the extracellular deposition of amyloid plaques. Here, we describe significant deposition of amyloid β (Aβ) in the cerebral vasculature [cerebral amyloid angiop...

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Bibliographic Details
Main Authors: Calhoun, Michael E., Burgermeister, Patrick, Phinney, Amie L., Stalder, Martina, Tolnay, Markus, Wiederhold, Karl-Heinz, Abramowski, Dorothee, Sturchler-Pierrat, Christine, Sommer, Bernd, Staufenbiel, Matthias, Jucker, Mathias
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 1999
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC24195/
https://ncbi.nlm.nih.gov/pubmed/10570203
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