Co-temporal Force and Fluorescence Measurements Reveal a Ribosomal Gear-shift Mechanism of Translation Regulation by mRNA Secondary Structures

Movement of ribosomes on mRNA is often interrupted by secondary structures that present mechanical barriers and play a central role in translation regulation. We investigate how ribosomes couple their internal conformational changes with the activity of translocation factor EF-G to unwind mRNA secon...

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發表在:Mol Cell
Main Authors: Desai, Varsha P., Frank, Filipp, Lee, Antony, Righini, Maurizio, Lancaster, Laura, Noller, Harry F., Tinoco, Ignacio, Bustamante, Carlos
格式: Artigo
語言:Inglês
出版: 2019
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6779417/
https://ncbi.nlm.nih.gov/pubmed/31471187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2019.07.024
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