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Mechanical force releases nascent chain–mediated ribosome arrest in vitro and in vivo

Protein synthesis rates can affect gene expression and the folding and activity of the translation product. Interactions between the nascent polypeptide and the ribosome exit tunnel represent one mode of regulating synthesis rates. The SecM protein arrests its own translation, and release of arrest...

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Bibliografiske detaljer
Udgivet i:Science
Main Authors: Goldman, Daniel H., Kaiser, Christian M., Milin, Anthony, Righini, Maurizio, Tinoco, Ignacio, Bustamante, Carlos
Format: Artigo
Sprog:Inglês
Udgivet: 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4618485/
https://ncbi.nlm.nih.gov/pubmed/25908824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1261909
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