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Mechanical force releases nascent chain–mediated ribosome arrest in vitro and in vivo

Protein synthesis rates can affect gene expression and the folding and activity of the translation product. Interactions between the nascent polypeptide and the ribosome exit tunnel represent one mode of regulating synthesis rates. The SecM protein arrests its own translation, and release of arrest...

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Vydáno v:Science
Hlavní autoři: Goldman, Daniel H., Kaiser, Christian M., Milin, Anthony, Righini, Maurizio, Tinoco, Ignacio, Bustamante, Carlos
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4618485/
https://ncbi.nlm.nih.gov/pubmed/25908824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1261909
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