KLF4 in Macrophages Attenuates TNFα-Mediated Kidney Injury and Fibrosis

BACKGROUND: Polarized macrophage populations can orchestrate both inflammation of the kidney and tissue repair during CKD. Proinflammatory M1 macrophages initiate kidney injury, but mechanisms through which persistent M1-dependent kidney damage culminates in fibrosis require elucidation. Krüppel-lik...

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Foilsithe in:J Am Soc Nephrol
Main Authors: Wen, Yi, Lu, Xiaohan, Ren, Jiafa, Privratsky, Jamie R., Yang, Bo, Rudemiller, Nathan P., Zhang, Jiandong, Griffiths, Robert, Jain, Mukesh K., Nedospasov, Sergei A., Liu, Bi Cheng, Crowley, Steven D.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society of Nephrology 2019
Ábhair:
Basic Research
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6779357/
https://ncbi.nlm.nih.gov/pubmed/31337692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2019020111
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