Cryo-EM structure of oxysterol-bound human Smoothened coupled to a heterotrimeric G(i)

The oncoprotein Smoothened (SMO), a Frizzled-Class (Class-F) G-protein-coupled receptor (GPCR), transduces the Hedgehog (HH) signal from the tumor suppressor Patched-1 (PTCH1) to the glioma-associated oncogene (GLI) transcription factors, activating the signaling pathway(1,2). It has remained a myst...

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Bibliographic Details
Published in:	Nature
Main Authors:	Qi, Xiaofeng, Liu, Heng, Thompson, Bonne, McDonald, Jeffrey, Zhang, Cheng, Li, Xiaochun
Format:	Artigo
Language:	Inglês
Published:	2019
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC6777001/ https://ncbi.nlm.nih.gov/pubmed/31168089 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-019-1286-0
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Cryo-EM structure of oxysterol-bound human Smoothened coupled to a heterotrimeric G(i)

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