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Cryo-EM structure of the adenosine A(2A) receptor coupled to an engineered heterotrimeric G protein
The adenosine A(2A) receptor (A(2A)R) is a prototypical G protein-coupled receptor (GPCR) that couples to the heterotrimeric G protein G(S). Here, we determine the structure by electron cryo-microscopy (cryo-EM) of A(2A)R at pH 7.5 bound to the small molecule agonist NECA and coupled to an engineere...
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| Pubblicato in: | eLife |
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| Autori principali: | , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
eLife Sciences Publications, Ltd
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5962338/ https://ncbi.nlm.nih.gov/pubmed/29726815 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.35946 |
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