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Cryo-EM structure of the adenosine A(2A) receptor coupled to an engineered heterotrimeric G protein

The adenosine A(2A) receptor (A(2A)R) is a prototypical G protein-coupled receptor (GPCR) that couples to the heterotrimeric G protein G(S). Here, we determine the structure by electron cryo-microscopy (cryo-EM) of A(2A)R at pH 7.5 bound to the small molecule agonist NECA and coupled to an engineere...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: García-Nafría, Javier, Lee, Yang, Bai, Xiaochen, Carpenter, Byron, Tate, Christopher G
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5962338/
https://ncbi.nlm.nih.gov/pubmed/29726815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.35946
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