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Engineering a minimal G protein to facilitate crystallisation of G protein-coupled receptors in their active conformation
G protein-coupled receptors (GPCRs) modulate cytoplasmic signalling in response to extracellular stimuli, and are important therapeutic targets in a wide range of diseases. Structure determination of GPCRs in all activation states is important to elucidate the precise mechanism of signal transductio...
Wedi'i Gadw mewn:
| Cyhoeddwyd yn: | Protein Eng Des Sel |
|---|---|
| Prif Awduron: | , |
| Fformat: | Artigo |
| Iaith: | Inglês |
| Cyhoeddwyd: |
Oxford University Press
2016
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| Pynciau: | |
| Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5181381/ https://ncbi.nlm.nih.gov/pubmed/27672048 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/protein/gzw049 |
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