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Conformational Transitions and the Activation of Heterotrimeric G Proteins by G Protein-Coupled Receptors

G protein-coupled receptors (GPCRs) are particularly attractive targets for therapeutic pharmaceuticals. This is because they are involved in almost all facets of physiology, in many pathophysiological processes, they are tractable due to their cell surface location, and can exhibit highly textured...

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Pubblicato in:ACS Pharmacol Transl Sci
Autori principali: Draper-Joyce, Christopher, Furness, Sebastian George Barton
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Chemical Society 2019
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7088962/
https://ncbi.nlm.nih.gov/pubmed/32259062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsptsci.9b00054
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