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Therapeutic targeting of 3’,5’-cyclic nucleotide phosphodiesterases: Inhibition and beyond

Phosphodiesterases (PDEs), enzymes that degrade 3’,5’-cyclic nucleotides, are being pursued as therapeutic targets for several diseases, including those affecting the nervous system, cardiovascular system, fertility, immunity, cancer, and metabolism. Clinical development programmes have focused excl...

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Bibliographische Detailangaben
Veröffentlicht in:Nat Rev Drug Discov
Hauptverfasser: Baillie, George S., Tejeda, Gonzalo S., Kelly, Michy P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6773486/
https://ncbi.nlm.nih.gov/pubmed/31388135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41573-019-0033-4
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