Activation of Group II Metabotropic Glutamate Receptors Inhibits Synaptic Excitation of the Substantia Nigra Pars Reticulata

Loss of nigrostriatal dopaminergic neurons in Parkinson's disease (PD) leads to increased activity of glutamatergic neurons in the subthalamic nucleus (STN). Recent studies reveal that the resultant increase in STN-induced excitation of basal ganglia output nuclei is responsible for the disabli...

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Bibliographic Details
Published in:J Neurosci
Main Authors: Bradley, Stefania Risso, Marino, Michael J., Wittmann, Marion, Rouse, Susan T., Awad, Hazar, Levey, Allan I., Conn, P. Jeffrey
Format: Artigo
Language:Inglês
Published: Society for Neuroscience 2000
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6773118/
https://ncbi.nlm.nih.gov/pubmed/10777772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.20-09-03085.2000
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