Activation of Group II Metabotropic Glutamate Receptors Inhibits Synaptic Excitation of the Substantia Nigra Pars Reticulata

Loss of nigrostriatal dopaminergic neurons in Parkinson's disease (PD) leads to increased activity of glutamatergic neurons in the subthalamic nucleus (STN). Recent studies reveal that the resultant increase in STN-induced excitation of basal ganglia output nuclei is responsible for the disabli...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Bradley, Stefania Risso, Marino, Michael J., Wittmann, Marion, Rouse, Susan T., Awad, Hazar, Levey, Allan I., Conn, P. Jeffrey
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2000
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ARTICLE
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6773118/
https://ncbi.nlm.nih.gov/pubmed/10777772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.20-09-03085.2000
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