Aging Increased Amyloid Peptide and Caused Amyloid Plaques in Brain of Old APP/V717I Transgenic Mice by a Different Mechanism than Mutant Presenilin1

Aging of transgenic mice that overexpress the London mutant of amyloid precursor protein (APP/V717I) (Moechars et al., 1999a) was now demonstrated not to affect the normalized levels of α- or β-cleaved secreted APP nor of the β-C-terminal stubs. This indicated that aging did not markedly disturb eit...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Dewachter, Ilse, Van Dorpe, Jo, Smeijers, Liesbet, Gilis, Martine, Kuipéri, Cuno, Laenen, Isabelle, Caluwaerts, Nathalie, Moechars, Dieder, Checler, Frédéric, Vanderstichele, Hugo, Van Leuven, Fred
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2000
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ARTICLE
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6772965/
https://ncbi.nlm.nih.gov/pubmed/10964951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.20-17-06452.2000
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