Dynorphin Promotes Abnormal Pain and Spinal Opioid Antinociceptive Tolerance

The nonopioid actions of spinal dynorphin may promote aspects of abnormal pain after nerve injury. Mechanistic similarities have been suggested between opioid tolerance and neuropathic pain. Here, the hypothesis that spinal dynorphin might mediate effects of sustained spinal opioids was explored. Po...

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Bibliografiske detaljer
Udgivet i:J Neurosci
Main Authors: Vanderah, Todd W., Gardell, Luis R., Burgess, Shannon E., Ibrahim, Mohab, Dogrul, Ahmet, Zhong, Cheng-Min, Zhang, En-Tan, Malan, T. Philip, Ossipov, Michael H., Lai, Josephine, Porreca, Frank
Format: Artigo
Sprog:Inglês
Udgivet: Society for Neuroscience 2000
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ARTICLE
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6772839/
https://ncbi.nlm.nih.gov/pubmed/10995854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.20-18-07074.2000
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