Tonic Descending Facilitation from the Rostral Ventromedial Medulla Mediates Opioid-Induced Abnormal Pain and Antinociceptive Tolerance

Many clinical case reports have suggested that sustained opioid exposure can elicit unexpected, paradoxical pain. Here, we explore the possibility that (1) opioid-induced pain results from tonic activation of descending pain facilitation arising in the rostral ventromedial medulla (RVM) and (2) the...

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Vydáno v:J Neurosci
Hlavní autoři: Vanderah, Todd W., Suenaga, Nova M. H., Ossipov, Michael H., Malan, T. Philip, Lai, Josephine, Porreca, Frank
Médium: Artigo
Jazyk:Inglês
Vydáno: Society for Neuroscience 2001
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6762454/
https://ncbi.nlm.nih.gov/pubmed/11150345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.21-01-00279.2001
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