Activation of Descending Pain Facilitatory Pathways from the Rostral Ventromedial Medulla by Cholecystokinin Elicits Release of PGE(2) in the Spinal Cord

Cholecystokinin (CCK) has been suggested to be both pro-nociceptive and anti-opioid by actions on pain modulatory cells within the RVM. One consequence of activation of RVM CCK(2) receptors may be enhanced spinal nociceptive transmission but how this might occur, especially in states of pathological...

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Main Authors: Marshall, Timothy M., Herman, David S., Largent-Milnes, Tally M., Badghisi, Hamid, Zuber, Konstantina, Holt, Shannon C., Lai, Josephine, Porreca, Frank, Vanderah, Todd W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3245767/
https://ncbi.nlm.nih.gov/pubmed/22030324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pain.2011.09.021
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