Cholecystokinin in the Rostral Ventromedial Medulla Mediates Opioid-Induced Hyperalgesia and Antinociceptive Tolerance

Opioid-induced hyperalgesia is characterized by hypersensitivity to innocuous or noxious stimuli during sustained opiate administration. Microinjection of lidocaine into the rostral ventromedial medulla (RVM), or dorsolateral funiculus (DLF) lesion, abolishes opioid-induced hyperalgesia, suggesting...

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Vydáno v:J Neurosci
Hlavní autoři: Xie, Jennifer Y., Herman, David S., Stiller, Carl-Olav, Gardell, Luis R., Ossipov, Michael H., Lai, Josephine, Porreca, Frank, Vanderah, Todd W.
Médium: Artigo
Jazyk:Inglês
Vydáno: Society for Neuroscience 2005
Témata:
Behavioral/Systems/Cognitive
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6725495/
https://ncbi.nlm.nih.gov/pubmed/15647484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4054-04.2005
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