Cholecystokinin in the Rostral Ventromedial Medulla Mediates Opioid-Induced Hyperalgesia and Antinociceptive Tolerance

Opioid-induced hyperalgesia is characterized by hypersensitivity to innocuous or noxious stimuli during sustained opiate administration. Microinjection of lidocaine into the rostral ventromedial medulla (RVM), or dorsolateral funiculus (DLF) lesion, abolishes opioid-induced hyperalgesia, suggesting...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Xie, Jennifer Y., Herman, David S., Stiller, Carl-Olav, Gardell, Luis R., Ossipov, Michael H., Lai, Josephine, Porreca, Frank, Vanderah, Todd W.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2005
Assuntos:
Behavioral/Systems/Cognitive
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6725495/
https://ncbi.nlm.nih.gov/pubmed/15647484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4054-04.2005
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