Cholecystokinin in the Rostral Ventromedial Medulla Mediates Opioid-Induced Hyperalgesia and Antinociceptive Tolerance

Opioid-induced hyperalgesia is characterized by hypersensitivity to innocuous or noxious stimuli during sustained opiate administration. Microinjection of lidocaine into the rostral ventromedial medulla (RVM), or dorsolateral funiculus (DLF) lesion, abolishes opioid-induced hyperalgesia, suggesting...

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Détails bibliographiques
Publié dans:J Neurosci
Auteurs principaux: Xie, Jennifer Y., Herman, David S., Stiller, Carl-Olav, Gardell, Luis R., Ossipov, Michael H., Lai, Josephine, Porreca, Frank, Vanderah, Todd W.
Format: Artigo
Langue:Inglês
Publié: Society for Neuroscience 2005
Sujets:
Behavioral/Systems/Cognitive
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6725495/
https://ncbi.nlm.nih.gov/pubmed/15647484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4054-04.2005
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