Sustained Morphine Exposure Induces a Spinal Dynorphin-Dependent Enhancement of Excitatory Transmitter Release from Primary Afferent Fibers

Paradoxical opioid-induced pain has been demonstrated repeatedly in humans and animals. The mechanisms of such pain are unknown but may relate to opioid-induced activation of descending pain facilitatory systems and enhanced expression and pronociceptive actions of spinal dynorphin. Here, the possib...

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Bibliografske podrobnosti
izdano v:J Neurosci
Main Authors: Gardell, Luis R., Wang, Ruizhong, Burgess, Shannon E., Ossipov, Michael H., Vanderah, Todd W., Malan, T. Philip, Lai, Josephine, Porreca, Frank
Format: Artigo
Jezik:Inglês
Izdano: Society for Neuroscience 2002
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ARTICLE
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6758163/
https://ncbi.nlm.nih.gov/pubmed/12151554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.22-15-06747.2002
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