Dynorphin Promotes Abnormal Pain and Spinal Opioid Antinociceptive Tolerance

The nonopioid actions of spinal dynorphin may promote aspects of abnormal pain after nerve injury. Mechanistic similarities have been suggested between opioid tolerance and neuropathic pain. Here, the hypothesis that spinal dynorphin might mediate effects of sustained spinal opioids was explored. Po...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Vanderah, Todd W., Gardell, Luis R., Burgess, Shannon E., Ibrahim, Mohab, Dogrul, Ahmet, Zhong, Cheng-Min, Zhang, En-Tan, Malan, T. Philip, Ossipov, Michael H., Lai, Josephine, Porreca, Frank
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2000
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ARTICLE
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6772839/
https://ncbi.nlm.nih.gov/pubmed/10995854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.20-18-07074.2000
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